| Rank | Player | Yd | TD | INT | Yd | TD | FL | FPTS | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Aaron Rodgers, GB | 4170 | 30 | 13 | 280 | 5 | 3 | 313 | |
| 2 | Tom Brady, NE | 4230 | 33 | 11 | 30 | 1 | 1 | 286 | |
| 3 | Michael Vick, PHI | 3090 | 24 | 12 | 500 | 7 | 3 | 282 | |
| 4 | Drew Brees, NO | 4540 | 32 | 19 | 30 | 0 | 2 | 271 | |
| 5 | Philip Rivers, SD | 4280 | 31 | 14 | 55 | 0 | 2 | 269 | |
| 6 | Tony Romo, DAL | 4450 | 30 | 16 | 65 | 0 | 3 | 267 | |
| 7 | Peyton Manning, IND | 4340 | 33 | 20 | 15 | 0 | 1 | 265 | |
| 8 | Matt Schaub, HOU | 4440 | 25 | 14 | 60 | 1 | 3 | 256 | |
| 9 | Ben Roethlisberger, PIT | 4140 | 25 | 11 | 100 | 1 | 3 | 254 | |
| 10 | Josh Freeman, TB | 3620 | 23 | 11 | 310 | 2 | 2 | 254 | |
| 11 | Matt Ryan, ATL | 3910 | 29 | 16 | 90 | 1 | 2 | 251 | |
| 12 | Eli Manning, NYG | 3990 | 28 | 19 | 60 | 0 | 3 | 234 | |
| 13 | Matthew Stafford, DET | 3940 | 25 | 16 | 40 | 1 | 3 | 230 | |
| 14 | Sam Bradford, STL | 4040 | 24 | 16 | 80 | 0 | 2 | 230 | |
| 15 | Jay Cutler, CHI | 3650 | 24 | 18 | 180 | 1 | 4 | 222 | |
| 16 | Joe Flacco, BAL | 3555 | 24 | 13 | 98 | 1 | 3 | 222 | |
| 17 | Kevin Kolb, ARI | 3475 | 23 | 18 | 190 | 2 | 4 | 218 | |
| 18 | Cam Newton, CAR | 3020 | 19 | 15 | 320 | 4 | 4 | 215 | |
| 19 | Jason Campbell, OAK | 3420 | 19 | 13 | 230 | 1 | 3 | 210 | |
| 20 | Matt Cassel, KC | 3235 | 22 | 14 | 160 | 1 | 2 | 207 | |
| 21 | Kyle Orton, DEN | 3340 | 20 | 14 | 130 | 1 | 0 | 205 | |
| 22 | Ryan Fitzpatrick, BUF | 3320 | 23 | 15 | 150 | 0 | 4 | 202 | |
| 23 | Donovan McNabb, MIN | 3280 | 22 | 17 | 120 | 1 | 3 | 197 | |
| 24 | Colt McCoy, CLE | 3090 | 20 | 14 | 175 | 1 | 2 | 195 | |
| 25 | Mark Sanchez, NYJ | 3340 | 20 | 17 | 130 | 1 | 3 | 193 | |
| 26 | Chad Henne, MIA | 3050 | 19 | 14 | 120 | 1 | 2 | 184 | |
| 27 | Matt Hasselbeck, TEN | 3240 | 20 | 17 | 50 | 1 | 3 | 181 | |
| 28 | Tavaris Jackson, SEA | 2770 | 16 | 16 | 300 | 1 | 2 | 175 | |
| 29 | David Garrard, JAC | 2250 | 16 | 10 | 210 | 2 | 2 | 163 | |
| 30 | Andy Dalton, CIN | 2460 | 15 | 14 | 140 | 1 | 3 | 144 | |
| 31 | John Beck, WAS | 2080 | 12 | 10 | 100 | 0 | 2 | 117 | |
| 32 | Alex Smith, SF | 1880 | 9 | 7 | 40 | 0 | 1 | 99 | |
| 33 | Tim Tebow, DEN | 700 | 4 | 5 | 260 | 6 | 0 | 96 | |
| 34 | Bruce Gradkowski, CIN | 1130 | 10 | 8 | 80 | 1 | 4 | 75 | |
| 35 | Rex Grossman, WAS | 1060 | 8 | 7 | 50 | 0 | 0 | 65 | |
| 36 | Colin Kaepernick, SF | 770 | 5 | 6 | 90 | 2 | 1 | 58 | |
| 37 | Charlie Whitehurst, SEA | 780 | 5 | 5 | 60 | 0 | 0 | 47 | |
| 38 | Jake Locker, TEN | 440 | 4 | 5 | 160 | 1 | 1 | 44 | |
| 39 | Christian Ponder, MIN | 680 | 6 | 4 | 30 | 0 | 2 | 42 | |
| 40 | Blaine Gabbert, JAC | 865 | 4 | 5 | 26 | 0 | 1 | 41 | |
| 41 | Shaun Hill, DET | 690 | 3 | 2 | 54 | 0 | 1 | 39 | |
| 42 | Vince Young, PHI | 360 | 3 | 2 | 30 | 0 | 0 | 25 | |
| 43 | Jimmy Clausen, CAR | 540 | 2 | 4 | 30 | 0 | 0 | 25 | |
| 44 | Matt Moore, MIA | 380 | 3 | 2 | 20 | 0 | 2 | 21 | |
| 45 | Jon Kitna, DAL | 220 | 2 | 2 | 10 | 0 | 0 | 14 |