| Rank | Player | Yrds | TD | Recpt | Yrds | TD | FL | FPTS | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Arian Foster, HOU | 1440 | 13 | 49 | 385 | 2 | 2 | 318 | |
| 2 | LeSean McCoy, PHI | 1105 | 7 | 73 | 610 | 3 | 2 | 301 | |
| 3 | Ray Rice, BAL | 1210 | 7 | 65 | 640 | 2 | 2 | 300 | |
| 4 | Jamaal Charles, KC | 1420 | 7 | 45 | 480 | 3 | 2 | 291 | |
| 5 | Darren McFadden, OAK | 1250 | 8 | 58 | 520 | 2 | 3 | 289 | |
| 6 | Chris Johnson, TEN | 1340 | 11 | 42 | 350 | 2 | 2 | 285 | |
| 7 | Adrian Peterson, MIN | 1420 | 12 | 38 | 330 | 1 | 3 | 285 | |
| 8 | Maurice Jones-Drew, JAC | 1260 | 8 | 47 | 445 | 2 | 2 | 274 | |
| 9 | Frank Gore, SF | 1130 | 7 | 54 | 490 | 2 | 2 | 266 | |
| 10 | Steven Jackson, STL | 1190 | 7 | 50 | 495 | 1 | 2 | 263 | |
| 11 | Matt Forte, CHI | 1090 | 5 | 55 | 560 | 3 | 3 | 262 | |
| 12 | Rashard Mendenhall, PIT | 1250 | 12 | 30 | 260 | 1 | 2 | 255 | |
| 13 | Peyton Hillis, CLE | 1060 | 10 | 45 | 400 | 1 | 3 | 251 | |
| 14 | Jahvid Best, DET | 920 | 6 | 52 | 450 | 2 | 2 | 233 | |
| 15 | Felix Jones, DAL | 990 | 5 | 48 | 410 | 3 | 2 | 232 | |
| 16 | Michael Turner, ATL | 1335 | 12 | 20 | 80 | 0 | 2 | 230 | |
| 17 | Ahmad Bradshaw, NYG | 1020 | 7 | 45 | 385 | 1 | 4 | 226 | |
| 18 | Knowshon Moreno, DEN | 1010 | 5 | 40 | 395 | 3 | 2 | 225 | |
| 19 | LeGarrette Blount, TB | 1200 | 10 | 25 | 190 | 0 | 4 | 216 | |
| 20 | Shonn Greene, NYJ | 1140 | 8 | 30 | 220 | 0 | 2 | 210 | |
| 21 | Ryan Mathews, SD | 980 | 7 | 39 | 240 | 2 | 4 | 207 | |
| 22 | Joseph Addai, IND | 930 | 7 | 35 | 250 | 2 | 1 | 205 | |
| 23 | DeAngelo Williams, CAR | 1030 | 7 | 35 | 210 | 1 | 2 | 203 | |
| 24 | Cedric Benson, CIN | 1090 | 6 | 30 | 210 | 1 | 3 | 196 | |
| 25 | Fred Jackson, BUF | 1080 | 5 | 30 | 220 | 1 | 1 | 194 | |
| 26 | Mark Ingram, NO | 1110 | 8 | 20 | 140 | 0 | 1 | 191 | |
| 27 | Tim Hightower, WAS | 920 | 6 | 34 | 290 | 0 | 1 | 189 | |
| 28 | Ryan Grant, GB | 1080 | 7 | 23 | 190 | 0 | 2 | 188 | |
| 29 | Beanie Wells, ARI | 980 | 6 | 30 | 210 | 1 | 2 | 187 | |
| 30 | Pierre Thomas, NO | 890 | 6 | 29 | 240 | 1 | 1 | 182 | |
| 31 | Daniel Thomas, MIA | 940 | 7 | 25 | 170 | 1 | 2 | 180 | |
| 32 | Mike Tolbert, SD | 740 | 8 | 32 | 220 | 1 | 1 | 180 | |
| 33 | BenJarvus Green-Ellis, NE | 910 | 10 | 15 | 90 | 0 | 1 | 173 | |
| 34 | Brandon Jacobs, NYG | 820 | 8 | 25 | 200 | 0 | 1 | 173 | |
| 35 | Marshawn Lynch, SEA | 950 | 6 | 22 | 130 | 0 | 2 | 162 | |
| 36 | Jonathan Stewart, CAR | 810 | 8 | 20 | 150 | 0 | 2 | 160 | |
| 37 | Ricky Williams, BAL | 660 | 5 | 34 | 250 | 1 | 1 | 159 | |
| 38 | Reggie Bush, MIA | 720 | 5 | 48 | 420 | 3 | 2 | 158 | |
| 39 | Jerome Harrison, DET | 580 | 4 | 35 | 310 | 2 | 2 | 156 | |
| 40 | James Starks, GB | 780 | 6 | 25 | 140 | 1 | 2 | 155 | |
| 41 | Darren Sproles, NO | 300 | 1 | 58 | 410 | 3 | 1 | 151 | |
| 42 | Ryan Torain, WAS | 700 | 5 | 23 | 170 | 1 | 2 | 142 | |
| 43 | Michael Bush, OAK | 690 | 7 | 20 | 150 | 0 | 2 | 142 | |
| 44 | Ronnie Brown, PHI | 490 | 4 | 36 | 300 | 1 | 2 | 141 | |
| 45 | Jason Snelling, ATL | 460 | 1 | 36 | 390 | 2 | 1 | 137 | |
| 46 | LaDainian Tomlinson, NYJ | 440 | 4 | 40 | 290 | 0 | 0 | 137 | |
| 47 | Marion Barber, CHI | 490 | 4 | 35 | 245 | 1 | 1 | 137 | |
| 48 | Tashard Choice, DAL | 680 | 4 | 28 | 150 | 0 | 1 | 133 | |
| 49 | C.J. Spiller, BUF | 460 | 3 | 39 | 280 | 1 | 3 | 131 | |
| 50 | Danny Woodhead, NE | 475 | 3 | 30 | 210 | 2 | 0 | 129 | |
| 51 | LaRod Stephens-Howling, ARI | 560 | 2 | 32 | 240 | 1 | 1 | 128 | |
| 52 | Mike Goodson, CAR | 380 | 3 | 38 | 330 | 1 | 3 | 127 | |
| 53 | Montario Hardesty, CLE | 560 | 4 | 29 | 180 | 0 | 0 | 127 | |
| 54 | Bernard Scott, CIN | 560 | 4 | 24 | 200 | 0 | 0 | 124 | |
| 55 | Donald Brown, IND | 390 | 1 | 30 | 380 | 2 | 1 | 123 | |
| 56 | Javon Ringer, TEN | 420 | 3 | 30 | 260 | 1 | 0 | 122 | |
| 57 | Rashad Jennings, JAC | 640 | 3 | 22 | 155 | 0 | 0 | 120 | |
| 58 | Earnest Graham, TB | 310 | 2 | 39 | 270 | 1 | 0 | 115 | |
| 59 | Willis McGahee, DEN | 525 | 5 | 21 | 125 | 0 | 2 | 112 | |
| 60 | Cadillac Williams, STL | 400 | 2 | 30 | 230 | 1 | 0 | 111 | |
| 61 | Thomas Jones, KC | 605 | 5 | 11 | 73 | 0 | 1 | 107 | |
| 62 | Ben Tate, HOU | 540 | 3 | 20 | 140 | 0 | 0 | 106 | |
| 63 | Isaac Redman, PIT | 510 | 5 | 16 | 85 | 0 | 1 | 104 | |
| 64 | Stevan Ridley, NE | 310 | 4 | 25 | 210 | 0 | 0 | 101 | |
| 65 | Jaquizz Rodgers, ATL | 280 | 0 | 30 | 340 | 1 | 0 | 98 | |
| 66 | Brandon Jackson, HOU | 460 | 4 | 18 | 80 | 0 | 0 | 96 | |
| 67 | Roy Helu, WAS | 540 | 3 | 15 | 95 | 0 | 2 | 93 | |
| 68 | Kendall Hunter, SF | 390 | 2 | 20 | 170 | 1 | 1 | 92 | |
| 69 | Jamie Harper, TEN | 230 | 0 | 34 | 260 | 1 | 1 | 87 | |
| 70 | Taiwan Jones, OAK | 300 | 2 | 28 | 110 | 1 | 0 | 87 | |
| 71 | Toby Gerhart, MIN | 300 | 2 | 28 | 110 | 1 | 0 | 87 | |
| 72 | Leon Washington, SEA | 290 | 0 | 25 | 200 | 2 | 1 | 84 | |
| 73 | Justin Forsett, SEA | 390 | 1 | 18 | 140 | 1 | 0 | 83 | |
| 74 | Derrick Ward, HOU | 320 | 2 | 16 | 110 | 0 | 0 | 71 | |
| 75 | DeMarco Murray, DAL | 300 | 2 | 15 | 105 | 0 | 0 | 68 | |
| 76 | Joe McKnight, NYJ | 195 | 1 | 16 | 120 | 0 | 1 | 52 |